REGIONAL AND SUBCELLULAR-DISTRIBUTION OF CYTOCHROME-P-450-DEPENDENT DRUG-METABOLISM IN MONKEY BRAIN - THE OLFACTORY-BULB AND THE MITOCHONDRIAL-FRACTION HAVE HIGH-LEVELS OF ACTIVITY

被引:42
作者
ISCAN, M
REUHL, K
WEISS, B
MAINES, MD
机构
[1] UNIV ROCHESTER,DEPT BIOPHYS,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,CTR ENVIRONM HLTH SCI,ROCHESTER,NY 14642
[3] RUTGERS STATE UNIV,DEPT PHARMACOL & TOXICOL,NEW BRUNSWICK,NJ 08903
关键词
D O I
10.1016/0006-291X(90)91972-U
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In brain of female monkey (M. fascicularis) the content of cytochrome P-450 and benzo(a)pyrene hydroxylase activity in the mitochondrial fraction exceeded that of the microsomes by more than 4-fold. The mitochondrial drug metabolism activity exhibited substrate specificity and, unlike the microsomes, did not catalyze 7-ethoxyresorufin O-deethylase reaction. Moreover, the rate of benzo(a)pyrene hydroxylase activity by both the mitochondrial and the microsomal fractions displayed regional variation with the olfactory bulb displaying the highest hydroxylase activity. In contrast, the microsomal 7-ethoxyresorufin O-deethylase activity was uniformally distributed in all brain regions. © 1990.
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页码:858 / 863
页数:6
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