SALIVARY HISTATIN AS AN INHIBITOR OF A PROTEASE PRODUCED BY THE ORAL BACTERIUM BACTEROIDES-GINGIVALIS

被引：78

作者：

NISHIKATA, M

KANEHIRA, T

OH, H

TANI, H

TAZAKI, M

KUBOKI, Y

机构：

[1] HOKKAIDO UNIV,SCH DENT,DEPT PREVENT DENT,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,SCH DENT,DEPT ORAL BIOCHEM,SAPPORO,HOKKAIDO 060,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 174卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)91463-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effect of histatin 5 from human parotid saliva on various proteases. Histatin 5 strongly inhibited a trypsin-like protease produced by Bacteroides gingivalis with an IC50 value of 55 nM. Clostripain was also inhibited (IC50=800 nM). Activities of other proteases were not affected significantly. Because B. gingivalis is a suspected periodontal pathogen and its proteolytic enzymes have been considered to be associated with periodontal tissue destruction, it is suggested that salivary histatins play a role as a preventive against periodontal disease. © 1991.

引用

页码：625 / 630

页数：6

共 19 条

[1] SYNTHESIS AND ANALYTICAL USE OF A HIGHLY SENSITIVE AND CONVENIENT SUBSTRATE OF ELASTASE [J].