RESOLUTION OF 9-(CIS-4, TRANS-5-BISHYDROXYMETHYLCYCLOPENT-2-EN-R-1-YL)-9H-ADENINE AND SELECTIVE-INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS BY THE (-) ENANTIOMER

被引：16

作者：

KATAGIRI, N ^{[1
]}

SHIRAISHI, T ^{[1
]}

SATO, H ^{[1
]}

TOYOTA, A ^{[1
]}

KANEKO, C ^{[1
]}

YUSA, K ^{[1
]}

OHHARA, T ^{[1
]}

TSURUO, T ^{[1
]}

机构：

[1] JAPANESE FDN CANC RES,CTR CANC CHEMOTHERAPY,TOSHIMA KU,TOKYO 170,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 01期

关键词：

D O I：

10.1016/0006-291X(92)91172-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two enantiomers of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine (BCA) which showed a potent and selective anti-HIV effects have been synthesized and evaluated against human immuno-deficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA is expressed solely by the (-) isomer. © 1992.

引用

页码：154 / 159

页数：6

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