DOMINANT GENES FOR COLORECTAL-CANCER ARE NOT RARE

被引：111

作者：

HOULSTON, RS

COLLINS, A

SLACK, J

MORTON, NE

机构：

[1] CRC Research Group in Genetic Epidemiology, Department of Community Medicine, Southampton General Hospital, Southampton

来源：

ANNALS OF HUMAN GENETICS | 1992年 / 56卷

关键词：

D O I：

10.1111/j.1469-1809.1992.tb01136.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic basis for colorectal cancer was investigated by complex segregation analysis of a published series of consecutive pedigrees ascertained through patients undergoing treatment for colorectal cancer. Analysis favoured a dominant gene or genes with a frequency of 0.006 with a lifetime penetrance of 0.63. These genes account for 81 % of colorectal cancer in patients under 35, however, by 65 about 85 % are phenocopies.

引用

页码：99 / 103

页数：5

共 19 条

[1] ALMA T, 1973, CLIN GASTROENTEROL, V2, P577
[2] SEGREGATION ANALYSIS OF HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER
BAILEYWILSON, JE
ELSTON, RC
SCHUELKE, GS
KIMBERLING, W
ALBANO, W
LYNCH, JF
LYNCH, HT
[J]. GENETIC EPIDEMIOLOGY, 1986, 3 (01) : 27 - 38
[3] BISHOP DT, 1990, CANCER SURV, V9, P585
[4] COMMON INHERITANCE OF SUSCEPTIBILITY TO COLONIC ADENOMATOUS POLYPS AND ASSOCIATED COLORECTAL CANCERS
CANNONALBRIGHT, LA
SKOLNICK, MH
BISHOP, T
LEE, RG
BURT, RW
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (09) : 533 - 537
[5] IDENTIFICATION OF A CHROMOSOME-18Q GENE THAT IS ALTERED IN COLORECTAL CANCERS
FEARON, ER
CHO, KR
NIGRO, JM
KERN, SE
SIMONS, JW
RUPPERT, JM
HAMILTON, SR
PREISINGER, AC
THOMAS, G
KINZLER, KW
VOGELSTEIN, B
[J]. SCIENCE, 1990, 247 (4938) : 49 - 56
[6] SCREENING AND GENETIC-COUNSELING FOR RELATIVES OF PATIENTS WITH COLORECTAL-CANCER IN A FAMILY CANCER CLINIC
HOULSTON, RS
MURDAY, V
HAROCOPOS, C
WILLIAMS, CB
SLACK, J
[J]. BRITISH MEDICAL JOURNAL, 1990, 301 (6748) : 366 - 368
[7] GENETIC EPIDEMIOLOGY OF BREAST-CANCER IN BRITAIN
ISELIUS, L
SLACK, J
LITTLER, M
MORTON, NE
[J]. ANNALS OF HUMAN GENETICS, 1991, 55 : 151 - 159
[8] KINSLER KW, 1991, SCIENCE, V253, P661
[9] GENETIC-ANALYSIS OF AN INHERITED PREDISPOSITION TO COLON CANCER IN A FAMILY WITH A VARIABLE NUMBER OF ADENOMATOUS POLYPS
LEPPERT, M
BURT, R
HUGHES, JP
SAMOWITZ, W
NAKAMURA, Y
WOODWARD, S
GARDNER, E
LALOUEL, JM
WHITE, R
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (13) : 904 - 908
[10] FAMILY STUDIES IN CANCER OF COLON AND RECTUM
LOVETT, E
[J]. BRITISH JOURNAL OF SURGERY, 1976, 63 (01) : 13 - 18

← 1 2 →