PITUITARY LACTOTROPHS - ENDOCRINE, PARACRINE, JUXTACRINE, AND AUTOCRINE INTERACTIONS

被引：32

作者：

BENJONATHAN, N

LIU, JW

机构：

[1] Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1992年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/1043-2760(92)90127-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The synthesis and release of PRL by the lactotrophs is subjected to multiple regulators that are classified into four categories: endocrine, paracrine, juxtacrine, and autocrine. Endocrine agents originate from the hypothalamus, gonads, and the posterior pituitary. Paracrine factors are produced by cells of the intermediate and anterior lobes. Juxtacrine transmitters arise from extracellular matrix and cells adjacent to the lactotrophs. Autocrine agents are synthesized by the lactotrophs themselves. Consequently, the overall secretory activity of the lactotrophs reflects a balance between local and distant releasing and inhibiting factors.

引用

收藏

页码：254 / 258

页数：5

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