THE BO-RBC-SCID MOUSE MODEL FOR EVALUATING THE EFFICACY OF ANTI-THEILERIAL DRUGS

被引：11

作者：

HAGIWARA, K ^{[1
]}

TSUJI, M ^{[1
]}

ISHIHARA, C ^{[1
]}

TAJIMA, M ^{[1
]}

KUROSAWA, T ^{[1
]}

IWAI, H ^{[1
]}

TAKAHASHI, K ^{[1
]}

机构：

[1] RAKUNO GAKUEN UNIV,SCH VET MED,582 MIDORIMACHI BUNKYODAI,EBETSU 069,JAPAN

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 1993年 / 23卷 / 01期

关键词：

THEILERIA-SERGENTI; SCID MICE; ANTI-THEILERIAL DRUGS;

D O I：

10.1016/0020-7519(93)90092-D

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We have previously developed a mouse model which allowed the proliferation of Theileria sergenti in severe combined immunodeficiency (SCID) mice with circulating bovine erythrocytes (Bo-RBC). In the present study, this model was utilized to test the efficacy of anti-theilerial drugs. Bo-RBC-SCID mice were created by giving periodic transfusions of T. sergenti-free Bo-RBC, and subsequently infecting with T. sergenti. Three anti-protozoal compounds, Pamaquine (Yamanouchi Pharmaceutical Co. Ltd), Ganaseg (Japan CIBA-GEIGY Ltd) and Buparvaquone (Coopers Animal Health Ltd), were subcutaneously administered into the mice at doses recommended for cattle therapy. Blood examinations demonstrated that all three drugs significantly reduced the level of parasitemia although Ganaseg was effective only at a dose five times higher than that recommended for cattle therapy. Administration of the drugs neither caused any sign of acute toxicity nor changed the rate of Bo-RBC in the SCID mice's circulating blood cells. The results indicate that the Bo-RBC-SCID mouse model may offer a useful in vivo system for evaluating the efficacy of anti-protozoal drugs against T. sergenti.

引用

页码：13 / 16

页数：4

共 9 条

[1] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE [J].

BOSMA, GC ;

CUSTER, RP ;

BOSMA, MJ .

NATURE, 1983, 301 (5900) :527-530

[2]

ISHIHARA T, 1977, Journal of the Japan Veterinary Medical Association, V30, P187

[3]

KAMIYAMA T, IN PRESS J PARASITOL

[4] ANTITHEILERIAL ACTIVITY OF BW720C (BUPARVAQUONE) - A COMPARISON WITH PARVAQUONE [J].

MCHARDY, N ;

WEKESA, LS ;

HUDSON, AT ;

RANDALL, AW .

RESEARCH IN VETERINARY SCIENCE, 1985, 39 (01) :29-33

[5] CHEMOTHERAPY OF THEILERIA-PARVA INFECTION [J].

MCHARDY, N ;

HAIGH, AJB ;

DOLAN, TT .

NATURE, 1976, 261 (5562) :698-699

[6]

MINAMI T, 1985, JPN J VET SCI, V47, P297

[7] IMMUNIZATION OF CATTLE USING VARYING INFECTIVE DOSES OF THEILERIA-PARVA-LAWRENCEI SPOROZOITES DERIVED FROM AN AFRICAN BUFFALO (SYNCERUS-CAFFER) AND TREATMENT WITH BUPARVAQUONE [J].

MUTUGI, JJ ;

YOUNG, AS ;

MARITIM, AC ;

LINYONYI, A ;

MBOGO, SK ;

LEITCH, BL .

PARASITOLOGY, 1988, 96 :391-402

[8]

TAKAHASHI K, 1976, Journal of the College of Dairying (Ebetsu), V6, P179

[9] THEILERIA-SERGENTI PROLIFERATES IN SCID MICE WITH BOVINE ERYTHROCYTE TRANSFUSION [J].

TSUJI, M ;

HAGIWARA, K ;

TAKAHASHI, K ;

ISHIHARA, C ;

AZUMA, I ;

SIDDIQUI, WA .

JOURNAL OF PARASITOLOGY, 1992, 78 (04) :750-752

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