USE OF THE MICRODIALYSIS TECHNIQUE IN THE MONITORING OF SUBCUTANEOUS TISSUE GLUCOSE-CONCENTRATION

被引:15
作者
MEYERHOFF, C
BISCHOF, F
MENNEL, FJ
STERNBERG, F
PFEIFFER, EF
机构
[1] Institut fur Diabetes Technologie, Universitat Ulm, D-7900 Ulm
关键词
GLUCOSE SENSOR; ENZYME ELECTRODE; GLUCOSE OXIDASE; SUBCUTANEOUS GLUCOSE CONCENTRATION; MICRODIALYSIS;
D O I
10.1177/039139889301600507
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
For some time the subcutaneous (s.c.) tissue has been the target for continuous glucose measurement. The microdialysis technique permits an extracellular region approach, which has been used for about two decades for measuring various metabolites in dialysates obtained from different body regions. By connecting a s.c. implanted microdialysis probe to a flow chamber of an amperometric glucose sensor, the procedure of glucose sensing was transferred to ex vivo. Using this device it was possible to obtain, for up to 24 hours, s.c. tissue glucose profiles of healthy and diabetic people. The microdialysis theory, the calibration process and other microdialysis technique applications are discussed in this paper. Although the combination of the microdialysis technique and amperometric glucose sensing requires certain technical equipment, the combination of microdialysis and glucose sensor seems to be a promising approach to a continuously functioning glucose sensing system.
引用
收藏
页码:268 / 275
页数:8
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