WATER-SOLID INTERACTIONS .1. A TECHNIQUE FOR STUDYING MOISTURE SORPTION/DESORPTION

被引：25

作者：

STUBBERUD, L ^{[1
]}

ARWIDSSON, HG ^{[1
]}

GRAFFNER, C ^{[1
]}

机构：

[1] UNIV OSLO,INST PHARM,N-0316 OSLO,NORWAY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 114卷 / 01期

关键词：

EQUILIBRIUM MOISTURE CONTENT; CLIMATIC TEST CHAMBER; DESICCATOR; MOISTURE SORPTION DESORPTION ISOTHERM; MOISTURE SORPTION KINETICS; HYGROSCOPICITY;

D O I：

10.1016/0378-5173(94)00212-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Moisture sorption and desorption have been characterized for active (naproxen and paracetamol) and inactive pharmaceutical solids by using a climatic test chamber. The relative humidity (RH) of the climatic test chamber was varied in the range from 15 to 90%. Equilibrium moisture content was achieved within a period of 2 h for slightly hygroscopic and moderately hygroscopic substances. For very hygroscopic substances equilibrium was reached within 2 h at low RH(< 60%), whereas more than 24 h were needed at high RH (> 60%). Moisture sorption isotherms were characterized by using the climatic test chamber and were found to be identical with moisture sorption isotherms characterized by desiccators.

引用

页码：55 / 64

页数：10

共 22 条

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