METABOLISM OF ALPHA-NAPHTHOFLAVONE BY RAT, MOUSE, RABBIT, AND HAMSTER LIVER-MICROSOMES

被引：15

作者：

BERGMAN, HB

BRYANT, BJ

NESNOW, S

机构：

[1] US EPA, HLTH EFFECTS RES LAB, DIV GENET TOXICOL, CARCINOGENESIS & METAB BRANCH MD68, RES TRIANGLE PK, NC 27711 USA

[2] NORTHROP SERV INC, RES TRIANGLE PK, NC 27709 USA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1984年 / 72卷 / 03期

关键词：

D O I：

10.1016/0041-008X(84)90123-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism of .alpha.-naphthoflavone (ANF) was studied in hepatic microsomes from rats, mice, rabbits and hamsters, species in which ANF exerted its biological activities. The major metabolites produced by all species were ANF-5,6-oxide, ANF-6-phenol and ANF-7,8-dihydrodiol. Minor metabolites produced by all species were ANF-5,6-dihydrodiol, ANF-7-phenol and ANF-9-phenol. The total rates of metabolism were similar within all species: 22-32 nmol ANF metabolized/15 min per mg protein. Mouse liver microsomes were .apprx. 1.7-2.9 times as active as the other species on a nanomole of cytochrome P-450 basis. The major sites of enzymatic oxidation were the 5,6 and 7,8 bonds of ANF where for all species, 49-71% and 15-46% of the total metabolism occurred, respectively.

引用

页码：469 / 475

页数：7

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