QUANTIFICATION OF PROSTAGLANDIN-E(1) RECEPTORS IN CAVERNOUS TISSUE OF MEN, MONKEYS AND DOGS

被引：13

作者：

ABOSEIF, S ^{[1
]}

RIEMER, RK ^{[1
]}

STACKL, W ^{[1
]}

LUE, T ^{[1
]}

TANAGHO, E ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT UROL,U-575,SAN FRANCISCO,CA 94143

来源：

UROLOGIA INTERNATIONALIS | 1993年 / 50卷 / 03期

关键词：

ERECTION; IMPOTENCE; PHARMACOLOGICAL ERECTION; PROSTAGLANDIN-E(1); VASOACTIVE AGENTS;

D O I：

10.1159/000282473

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prostaglandin E1 (PGE1) has been shown to relax the muscles of the corpora cavernosa and inhibit spontaneous activity, and clinical trials have proved its safety and effectiveness when given intracavernously to induce erection. Through use of a specific PGE1 receptor binding assay, we undertook this study to quantify its receptor density and measure binding affinity. The cavernous tissue of normal and impotent men as well as that of monkeys and dogs was studied in an attempt to understand their different responses to the intracavernous injection of PGE1. Our results showed a lower receptor density in impotent men than in normal men and monkeys and a complete absence of receptors in dogs. These findings correlated well with the clinical response to intracavernous injection of PGE1.

引用

页码：148 / 152

页数：5