ELEVATED LEVELS OF EUKARYOTIC TRANSLATION INITIATION-FACTOR EIF-4E, MESSENGER-RNA IN A BROAD-SPECTRUM OF TRANSFORMED-CELL LINES

被引：64

作者：

MIYAGI, Y ^{[1
]}

SUGIYAMA, A ^{[1
]}

ASAI, A ^{[1
]}

OKAZAKI, T ^{[1
]}

KUCHINO, Y ^{[1
]}

KERR, SJ ^{[1
]}

机构：

[1] NATL CANC CTR, RES INST, DIV BIOPHYS, CHUO KU, TOKYO 104, JAPAN

来源：

CANCER LETTERS | 1995年 / 91卷 / 02期

关键词：

EIF-4E MESSENGER-RNA; PROTEIN SYNTHESIS; TRANSFORMATION; CARCINOGENESIS;

D O I：

10.1016/0304-3835(95)03737-H

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Translation initiation factor eIF-4E, which binds to the 5' cap structure of eukaryotic mRNAs, is believed to play an important role in the control of cell growth. Over-expression of eIF-4E in fibroblasts results in their malignant transformation. However, no information on eIF-4E expression in established transformed cell lines has been available. We report here that a variety of tumor Cell lines, chemically, virally and oncogenically transformed, exhibit elevated levels of eIF-4E mRNA expression as compared to their normal counterparts. Overexpression of eIF-4E, which is normally rate-limiting in protein synthesis, may stimulate the translation of regulatory and oncogenic proteins involved in transformation.

引用

页码：247 / 252

页数：6

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