A SUBCLASS OF BHLH PROTEINS REQUIRED FOR CARDIAC MORPHOGENESIS

被引：434

作者：

SRIVASTAVA, D ^{[1
]}

CSERJESI, P ^{[1
]}

OLSON, EN ^{[1
]}

机构：

[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT BIOCHEM & MOLEC BIOL, HOUSTON, TX 77030 USA

来源：

SCIENCE | 1995年 / 270卷 / 5244期

关键词：

D O I：

10.1126/science.270.5244.1995

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skeletal muscle development is controlled by a family of muscle-specific basic helix-loop-helix (bHLH) transcription factors. Two bHLH genes, dHAND and eHAND, have now been isolated that are expressed in the bilateral heart primordia and subsequently throughout the primitive tubular heart and its derivatives during chick and mouse embryogenesis. Incubation of stage 8 chick embryos with dHAND and eHAND antisense oligonucleotides revealed that either oligonucleotide alone had no effect on embryonic development, whereas together they arrested development at the looping heart tube stage. Thus, dHAND and eHAND may play redundant roles in the regulation of the morphogenetic events of vertebrate heart development.

引用

页码：1995 / 1999

页数：5

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