DETERMINATION OF OCTANOL-WATER PARTITION-COEFFICIENTS USING GRADIENT LIQUID-CHROMATOGRAPHY

被引：14

作者：

MAKOVSKAYA, V

DEAN, JR

TOMLINSON, WR

HITCHEN, SM

COMBER, M

机构：

[1] NORTHUMBRIA UNIV,DEPT CHEM & LIFE SCI,NEWCASTLE TYNE NE1 8ST,TYNE & WEAR,ENGLAND

[2] ZENECA LTD,BRIXHAM ENVIRONM LAB,BRIXHAM TQ5 8BA,DEVON,ENGLAND

来源：

ANALYTICA CHIMICA ACTA | 1995年 / 315卷 / 1-2期

关键词：

OCTANOL-WATER PARTITION COEFFICIENT; LIQUID CHROMATOGRAPHY; ENVIRONMENTAL ANALYSIS;

D O I：

10.1016/0003-2670(95)00295-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of liquid chromatography to estimate octanol-water partition coefficients, log k(ow), has been demonstrated. Tne capacity factor with a mobile phase of 100% water, k(w), has been found to be a useful chromatographic parameter. Values of k(w) were derived from a computer software package (Hipac-G), designed for optimization and simulation of gradient LC systems. The chromatographic parameter, k(w), correlates well with both literature and isocratic LC-generated log k(o)w values. The gradient LC method could be extended to a wider range of test compounds.

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页码：183 / 192

页数：10

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