THE ISOLATION OF TETRAHYDROXY BILE-ACIDS AS METHYL-ESTERS FROM HUMAN-URINE AND THEIR CHARACTERIZATION BY H-1-NUCL AND C-13-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY

被引：17

作者：

BACK, P ^{[1
]}

FRITZ, H ^{[1
]}

POPULOH, C ^{[1
]}

机构：

[1] UNIV FREIBURG, CHEM LAB, D-7800 FREIBURG, FED REP GER

来源：

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE | 1984年 / 365卷 / 04期

关键词：

D O I：

10.1515/bchm2.1984.365.1.479

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment with phenobarbital causes an increased urinary excretion of tetrahydroxylated bile acids in patients suffering from intrahepatic cholestasis. The main components were isolated from urine by means of column and TLC and were studied as methyl esters by CMR spectroscopy. The main components evidently are 1.beta.-, 6.alpha.- and 6.beta.-hydroxylated derivatives of cholic acid.

引用

页码：479 / 484

页数：6

共 16 条

[1]

ALME B, 1977, J LIPID RES, V18, P339

[2]

ALME B, 1976, LIVER QUANTITATIVE A, P227

[3] PHENOBARBITAL-INDUCED ALTERATIONS OF BILE-ACID METABOLISM IN CASES OF INTRA-HEPATIC CHOLESTASIS [J].