UNRELATED CLONAL CHROMOSOMAL-ABERRATIONS IN CARCINOMAS OF THE ORAL CAVITY

被引：39

作者：

JIN, YH ^{[1
]}

HEIM, S ^{[1
]}

MANDAHL, N ^{[1
]}

BJORKLUND, A ^{[1
]}

WENNERBERG, J ^{[1
]}

MITELMAN, F ^{[1
]}

机构：

[1] UNIV LUND HOSP,DEPT OTORHINOLARYNGOL,S-22185 LUND,SWEDEN

来源：

GENES CHROMOSOMES & CANCER | 1990年 / 1卷 / 03期

关键词：

D O I：

10.1002/gcc.2870010304

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Short‐term cultures from 12 oral squamous cell carcinomas were cytogenetically investigated. A normal karyotype was found in 3 tumors, 2 of which had many nonclonal changes. Clonal chromosome abnormalities were detected in the remaining 9 cases, in 6 of them in the form of 2 or 3 abnormal clones. In 5 cases the different clones were cytogenetically unrelated, suggesting a multiclonal origin. Numerous additional nonclonal changes were present in 4 of the 9 tumors with clonal aberrations. None of the structural aberrations, clonal or nonclonal, were found in more than one case; nor did any of the rearrangements correspond to cancer‐associated aberrations known from other tumors. The aberration breakpoints of the present series and of a previously reported tongue cancer clustered to bands 1p32, 1p22, 1p11, 1q21, 1q23, 1q25, 1q32, 1q42, 1q44, 2q31, 3p11, 4q35, 7p22, 11p15, 11q13, 12q24, and 17q25. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：209 / 215

页数：7

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