CLINICAL-APPLICATIONS OF STEM-CELL TRANSFUSION FROM CORD BLOOD

被引：11

作者：

GLUCKMAN, E

THIERRY, D

LESAGE, S

TRAINEAU, R

GEROTTA, J

RABIAN, C

BROSSARD, Y

VANNIFTERIK, J

BENBUNAN, M

机构：

[1] Bone Marrow Transplant Unit, Laboratory of Stem Cell Biology, Hôpital Saint Louis, Paris

[2] Immunology Department, Hôpital Saint Louis, Paris

[3] Blood Bank, Hôpital Saint Louis, Paris

[4] Neonatology Center, Hôpital Saint Antoine, Paris

[5] Department of Obstetrics, Hôpital Saint Vincent de Paul, Paris

来源：

TRANSFUSION SCIENCE | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0955-3886(92)90026-D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Umbilical cord blood collected and cryopreserved at birth contains enough hematopoietic progenitor stem cells for engraftment. HLA identical sibling cord blood transplantation has been performed for the first time in a child with Fanconi's anemia. This child is alive 3 years later with a complete donor type bone marrow. Since this first attempt, several other patients with other diseases have been transplanted successfully. Cord blood banking is a safe and easy procedure. Due to the high proliferative capacity of neonatal hematopoietic progenitors and to the relative immunological functional immaturity of neonatal lymphocytes, cord blood cells could be used for matched unrelated or partially mismatched transplants.

引用

页码：415 / 421

页数：7

共 16 条

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