CLONING AND SEQUENCING OF A RAT TYPE-II ACTIVIN RECEPTOR

被引：38

作者：

SHINOZAKI, H

ITO, I

HASEGAWA, Y

NAKAMURA, K

IGARASHI, S

NAKAMURA, M

MIYAMOTO, K

ETO, Y

IBUKI, Y

MINEGISHI, T

机构：

[1] GUNMA UNIV,SCH MED,DEPT OBSTET & GYNECOL,MAEBASHI,GUNMA 371,JAPAN

[2] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

[3] AJINOMOTO CO INC,CENT RES LABS,KAWASAKI,KANAGAWA 210,JAPAN

来源：

FEBS LETTERS | 1992年 / 312卷 / 01期

关键词：

OVARY; ACTIVIN RECEPTOR; MESSENGER RNA;

D O I：

10.1016/0014-5793(92)81408-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A full-length cDNA for a rat type II activin receptor was cloned by hybridization from a rat ovary cDNA library. The deduced amino acid sequence (513 residues) containing a single membrane-spanning domain and an intracellular kinase domain with predicted serine/threonine specificity. The amino acid sequence is 99.8% and 99.4% identical in the coding region with the previously cloned mouse and human type II activin receptor, and only 66.7% identical in the coding region with the previously cloned rat type IIB activin receptor. We examined the effect of PMSG-hCG on the mRNA level of type II activin receptor in immature rat ovaries. Northern blot analysis of ovarian RNA revealed two mRNAs (3.0 kb and 6.0 kb).

引用

页码：53 / 56

页数：4

共 32 条

[1] NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].