IGF-II MESSENGER-RNA EXPRESSION IN LI HUMAN GLIOBLASTOMA CELL-LINE PARALLELS CELL-GROWTH

被引：13

作者：

MELINO, G

STEPHANOU, A

ANNICCHIARICOPETRUZZELLI, M

FINAZZIAGRO, A

KNIGHT, RA

LIGHTMAN, SL

机构：

[1] NATL HEART & LUNG INST,LONDON,ENGLAND

[2] CHARING CROSS HOSP,LONDON W6 8RP,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1992年 / 144卷 / 1-2期

关键词：

GLIOBLASTOMA; INSULIN-LIKE GROWTH FACTOR-II; GROWTH HORMONE-RELEASING HORMONE; RETINOIC ACID; ALPHA-DIFLUOROMETHYLORNITHINE;

D O I：

10.1016/0304-3940(92)90707-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A human glioblastoma cell line was found to express in vitro mRNA transcripts specific for insulin-like growth factor-II (IGF-II) and growth-hormone releasing-hormone (GHRH). In the absence of gross morphological changes, retinoic acid reduced the growth rate without major change of IGF-II mRNA expression. while alpha-difluoromethylornithine produced a complete growth arrest and a sharp decrease of IGF-II mRNA expression. Both reagents increased the expression of GHRH mRNA. Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II mRNA is expressed independently from GHRH and seems to be parallel to growth rate.

引用

页码：25 / 28

页数：4

共 20 条

[1] DEVELOPMENTAL PATTERNS OF INSULIN-LIKE GROWTH FACTOR-I AND FACTOR-II SYNTHESIS AND REGULATION IN RAT FIBROBLASTS [J].