HOUSING OF PREGNANT RATS IN METABOLISM CAGES - MATERNAL AND DEVELOPMENTAL EFFECTS

被引:12
作者
BOSQUE, MA
DOMINGO, JL
CORBELLA, J
机构
[1] UNIV ROVIRA & VIRGILI,SCH MED,TOXICOL & BIOCHEM LAB,E-43201 REUS,SPAIN
[2] UNIV BARCELONA,SCH MED,DEPT PATHOL,REUS,SPAIN
关键词
PREGNANT RATS; METABOLISM CAGES; FOOD CONSUMPTION; BODY WEIGHT; PREGNANCY OUTCOME;
D O I
10.1016/S0940-2993(11)80106-5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The influence of the caging conditions on maternal and gestational variables was assessed for pregnant rats housed individually in two cage types. Plug positive Sprague-Dawley females were caged either in Makrolon or in metabolism (Tecniplast) cages, and were not disturbed throughout all the gestational period. Cesarean sections were performed on gestation day 20. All live fetuses were examined for external, internal, and skeletal malformations and variations. Pregnant rats were affected by the housing system, as evidenced by a significant weight loss and reduced food consumption in the animals housed in metabolism cages. A moderate increase in the number of total skeletal defects was also observed in the fetuses of dams housed in metabolism cages. An important implication of these results would be that in maternal and developmental toxicity studies of xenobiotics, pregnant animals should not be housed in metabolism cages.
引用
收藏
页码:303 / 306
页数:4
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