SUCCESSFUL TREATMENT OF MENINGITIS DUE TO MULTIPLY RESISTANT ENTEROCOCCUS-FAECIUM WITH A COMBINATION OF INTRATHECAL TEICOPLANIN AND INTRAVENOUS ANTIMICROBIAL AGENTS

被引：38

作者：

LOSONSKY, GA

WOLF, A

SCHWALBE, RS

NATARO, J

GIBSON, CB

LEWIS, EW

机构：

[1] UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV PEDIAT INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201

[2] UNIV MARYLAND,SCH MED,DEPT PATHOL,BALTIMORE,MD 21201

[3] UNIV MARYLAND,SCH MED,DEPT NEUROSURG,BALTIMORE,MD 21201

[4] UNIV MARYLAND,SCH MED,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21201

[5] MARION MERRELL DOW INC,ANTI INFECT CLIN RES GRP,KANSAS CITY,MO

来源：

CLINICAL INFECTIOUS DISEASES | 1994年 / 19卷 / 01期

关键词：

D O I：

10.1093/clinids/19.1.163

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following neurosurgery necessitated by intractable seizures, Enterococcus faecium meningitis that was resistant to ampicillin, a high-level aminoglycoside (MIC, >2,000 mu g/mL), and vancomycin developed in a 6-year-old boy. Treatment with intrathecal teicoplanin in combination with intravenous clindamycin, rifampin, and ampicillin was successful. The role of intravenous and intrathecal antibiotics in treatment of this infection is discussed. This case is illustrative of the safety and potential usefulness of intrathecally administered teicoplanin.

引用

收藏

页码：163 / 165

页数：3

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