QUANTIFYING THE EFFECT OF ISCHEMIA ON EPIPHYSEAL GROWTH IN AN EXTREMITY REPLANT MODEL

被引：10

作者：

CAREY, LA ^{[1
]}

WEISS, APC ^{[1
]}

WEILAND, AJ ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT ORTHOPAED SURG,BALTIMORE,MD 21205

来源：

JOURNAL OF HAND SURGERY-AMERICAN VOLUME | 1990年 / 15A卷 / 04期

关键词：

D O I：

10.1016/S0363-5023(09)90026-0

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Warm ischemia (21°C) of 0, 2, 4, 6, or 8 hours was produced in a modified hindlimb preparation of 35 10-week-old Lewis rats by amputation. Subsequent microvascular anastomoses of each hindlimb to a syngeneic animal was done after which fluorochrome bone labels were administered 5 minutes after operation and on day 14 after operation. Epiphyseal plate growth (that between bone labels) was analyzed histomorphometrically and statistically. Epiphyseal plate growth was found to have a linear inverse relationship to ischemia time with a correlation coefficient (r) of −0.653 and high statistical significance (p < 0.001). Overgrowth occurred at all ischemic periods except 8 hours, and vascular pedicle patency decreased as ischemia time progressed. © 1990, American Society for Surgery of the Hand. All rights reserved.

引用

页码：625 / 630

页数：6

共 27 条

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