THE EFFECT OF METHAMPHETAMINE ON THE RELEASE OF GLUTAMATE FROM STRIATAL SLICES

被引：12

作者：

EARLE, ML ^{[1
]}

DAVIES, JA ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT PHARMACOL & THERAPEUT,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1991年 / 86卷 / 03期

关键词：

STRIATAL SLICES; GLUTAMATE; DOPAMINE; METHAMPHETAMINE;

D O I：

10.1007/BF01250707

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One postulated role of dopamine in the striatum is to reduce neuronal activity in cortico-striatal glutamergic terminals. We investigated the effects of methamphetamine, which displaces dopamine, on glutamate release from rat striatal slices. Methamphetamine significantly reduced K+-stimulated (45 mM) glutamate release. In slices prepared from rats treated 8 days previously with methamphetamine there was enhanced (approximately 200%) release of glutamate. This study demonstrates that dopamine has a modulatory effect on glutamate release in the striatum.

引用

页码：217 / 222

页数：6

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