PROPERTIES OF THE LEAKAGE CURRENT PATHWAY - EFFECTS OF THE GADOLINIUM ION ON MYELINATED AXONS

被引：6

作者：

ELINDER, F ^{[1
]}

ARHEM, P ^{[1
]}

机构：

[1] KAROLINSKA INST,NOBEL INST NEUROPHYSIOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

NEUROREPORT | 1991年 / 2卷 / 11期

关键词：

GADOLINIUM; LEAKAGE CURRENT; MYELINATED AXON; NODE OF RANVIER; VOLTAGE CLAMP;

D O I：

10.1097/00001756-199111000-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

VOLTAGE-Clamp experiments on myelinated axons revealed that the trivalent gadoliniumion ion blocked the leakage current in a dose-dependent manner. The block showed 1:2 stoichiometry, and 50% reduction at 700-mu-M. Na+ and K+ currents were blocked at ten times lower concentration and showed 1:1 stoichiometry. Comparisons with biochemical studies suggest that the leakage current directly depends on a phospholipid pathway in contrast to the protein-channel dependent Na+ and K+ currents. The results may be explained by a leakage current pathway located at the interface between channel proteins and the lipid phase.

引用

页码：685 / 687

页数：3

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