ACCUMULATIONS OF INOSITOL PHOSPHATES AND CYCLIC-AMP IN BRAIN-SLICES - SYNERGISTIC INTERACTIONS OF HISTAMINE AND 2-CHLOROADENOSINE

被引：69

作者：

HOLLINGSWORTH, EB ^{[1
]}

DELACRUZ, RA ^{[1
]}

DALY, JW ^{[1
]}

机构：

[1] NIADDKD, BLDG 4, ROOM 212, BETHESDA, MD 20205 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1986年 / 122卷 / 01期

关键词：

D O I：

10.1016/0014-2999(86)90156-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

2-Chloroadenosine, 5''-N-ethylcarboxamidoadenosine, N6-cyclohexyladenosine and other adenosine analogs enhance histamine-elicited, but not norepinephrine- or carbamylcholine-elicited accumulations of inositol phosphates in [3H]inositol-labeled guinea-pig cerebral cortical slices. The adenosine analogs alone have no effect on accumulations of inositol phosphates. The effect of 2-chloroadenosine is blocked by the adenosine receptor antagonists theophylline and 1,3-dialkyl-8-p-sulfophenylxanthines. The rank order of activity of the six adenosine analogs with respect to augmentation of histamine-elicited accumulation inositol phosphates in guinea-pig cerebral cortical slices is different from the rank order at an A2-adenosine receptor that mediates synergistic accumulations of cyclic AMP by adenosine analogs and histamine in guinea-pig cerebral cortical slices.

引用

页码：45 / 50

页数：6

共 23 条

[1] H1 AND H2 RECEPTORS IN HISTAMINE-INDUCED ACCUMULATION OF CYCLIC-AMP IN GUINEA-PIG BRAIN-SLICES [J].