NEGATIVE INOTROPIC EFFECTS OF CYTOKINES ON THE HEART MEDIATED BY NITRIC-OXIDE

被引：1435

作者：

FINKEL, MS

ODDIS, CV

JACOB, TD

WATKINS, SC

HATTLER, BG

SIMMONS, RL

机构：

[1] UNIV PITTSBURGH, SCH MED, DEPT NEUROBIOL ANAT & CELL SCI, PITTSBURGH, PA 15213 USA

[2] UNIV PITTSBURGH, SCH MED, DEPT PHARMACOL, PITTSBURGH, PA 15213 USA

[3] UNIV PITTSBURGH, SCH MED, DEPT SURG, PITTSBURGH, PA 15213 USA

来源：

SCIENCE | 1992年 / 257卷 / 5068期

关键词：

D O I：

10.1126/science.1631560

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The direct effects of pro-inflammatory cytokines on the contractility of mammalian heart were studied. Tumor necrosis factor-alpha, interleukin-6, and interleukin-2 inhibited contractility of isolated hamster papillary muscles in a concentration-dependent, reversible manner. The nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) blocked these negative inotropic effectS. L-Arginine reversed the inhibition by L-NMMA. Removal of the endocardial endothelium did not alter these responses. These findings demonstrate that the direct negative inotropic effect of cytokines is mediated through a myocardial nitric oxide synthase. The regulation of pro-inflammatory cytokines and myocardial nitric oxide synthase may provide new therapeutic strategies for the treatment of cardiac disease.

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收藏

页码：387 / 389

页数：3

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