ANTIBIOTICS FROM BASIDIOMYCETES .41. CLAVICORONIC ACID, A NOVEL INHIBITOR OF REVERSE TRANSCRIPTASES FROM CLAVICORONA-PYXIDATA (PERS EX FR) DOTY

被引：28

作者：

ERKEL, G

ANKE, T

GIMENEZ, A

STEGLICH, W

机构：

[1] UNIV KAISERSLAUTERN,LB BIOTECHNOL,W-6750 KAISERSLAUTERN,GERMANY

[2] UNIV BONN,INST ORGAN CHEM & BIOCHEM,W-5300 BONN,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 01期

关键词：

D O I：

10.7164/antibiotics.45.29

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130-mu-M) and Moloney murine leukemia virus (Ki 68-mu-M) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

引用

页码：29 / 37

页数：9

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