PROCESSING AND LOCALIZATION OF DENGUE VIRUS TYPE-2 POLYPROTEIN PRECURSOR NS3-NS4A-NS4B-NS5

被引：98

作者：

ZHANG, LW ^{[1
]}

MOHAN, PM ^{[1
]}

PADMANABHAN, R ^{[1
]}

机构：

[1] UNIV KANSAS, MED CTR, DEPT BIOCHEM & MOLEC BIOL, KANSAS CITY, KS 66103 USA

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 12期

关键词：

D O I：

10.1128/JVI.66.12.7549-7554.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.

引用

页码：7549 / 7554

页数：6

共 31 条

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