A PROBABILISTIC APPROACH TO THE SINGLE-POINT, SINGLE-DOSE PROBLEM

被引：2

作者：

BRIGGS, WL

PHELPS, RW

SWANSON, GD

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT ANESTHESIOL,DENVER,CO 80202

[2] UNIV COLORADO,HLTH SCI CTR,DEPT BIOMETR,DENVER,CO 80202

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 1990年 / 37卷 / 01期

关键词：

D O I：

10.1109/10.43619

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A general probabilistic approach is applied to the single-point, single-dose method for estimating individual infusion rates and serum drug concentrations. By using transformations of probability density functions, the effects of variations in the elimination rate constant upon pharmacokinetic variables may be studied and optimal sampling times may be chosen. Although this study treats the case of error-free sampling in a single-compartment model with a normal distribution of rate constants, the methods presented can be extended to more general situations. © 1990 IEEE

引用

页码：80 / 84

页数：5

共 5 条

[1] OPTIMAL SAMPLING TIMES FOR MINIMUM VARIANCE OF CLEARANCE DETERMINATION [J].