VACCINIA VIRUS-MEDIATED DAMAGE OF MURINE OVARIES AND PROTECTION BY VIRUS-EXPRESSED INTERLEUKIN-2

被引：35

作者：

KARUPIAH, G

COUPAR, B

RAMSHAW, I

BOYLE, D

BLANDEN, R

ANDREW, M

机构：

[1] CSIRO,AUSTRALIAN ANIM HLTH LAB,PO BAG 24,GEELONG,VIC 3200,AUSTRALIA

[2] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CELL BIOL,CANBERRA,ACT 2601,AUSTRALIA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1990年 / 68卷

关键词：

D O I：

10.1038/icb.1990.44

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vaccinia virus was shown to replicate in the ovaries of normal inbred mice and cause sufficient damage to ovarian follicles to decrease fertility of the mice. The mouse-adapted strain, VV-WR, had a greater affinity for growth in ovaries than the vaccine strains, VV-Elstree, VV-NYBH or VV-Copenhagen. Virus reached the ovaries after intravenous or intraperitoneal inoculation, but not after subcutaneous inoculation in the foot pad. Interleukin-2 (IL-2), when expressed by a recombinant vaccinia virus was able to decrease the titre of virus in the ovaries and prevent infertility. Both non-specific (natural killer cells) and antigen-specific mechanisms were active within the ovaries and may play a role in the IL-2-mediated clearance of vaccinia virus.

引用

页码：325 / 333

页数：9

共 15 条

[1] HUMORAL AND CELL-MEDIATED IMMUNE-RESPONSES TO RECOMBINANT VACCINIA VIRUSES IN MICE [J].