ASSIGNMENT OF THE HUMAN 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE GENE TO CHROMOSOME-17

被引：10

作者：

SPRINKLE, TJ ^{[1
]}

LANCLOS, KD ^{[1
]}

LAPP, DF ^{[1
]}

机构：

[1] MED COLL GEORGIA,DEPT NEUROL,AUGUSTA,GA 30912

来源：

GENOMICS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90174-Q

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

2′,3′-Cyclic nucleotide 3′-phosphohydrolase (CNP) has been used as a general oligodendrocyte and Schwann cell marker enzyme within the nervous system and has been the intense target of a number of recent studies. In this report, we determined the chromosomal localization of the human CNP gene using PCR on two somatic cell DNA panels. PCR amplification, using four primer pairs across an intron, confirms that the CNP gene is localized to chromosome 17. We also present the complete intron sequence of the human gene used to make the assignment. This intron contains ac → t polymorphism located at nucleotide 1215, which may be of use in mapping the CNPase gene more precisely within chromosome 17. © 1992.

引用

页码：877 / 880

页数：4

共 5 条

[1] 2',3' CYCLIC NUCLEOTIDE-3'-PHOSPHODIESTERASE IN PERIPHERAL-NERVE MYELIN IS PHOSPHORYLATED BY A PHORBOL ESTER-SENSITIVE PROTEIN-KINASE [J].