(+/-)-5'-NOR-RIBOFURANOSIDE CARBOCYCLIC GUANOSINE

被引：14

作者：

PATIL, SD ^{[1
]}

SCHNELLER, SW ^{[1
]}

机构：

[1] UNIV S FLORIDA, DEPT CHEM, TAMPA, FL 33620 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 03期

关键词：

D O I：

10.1002/jhet.5570280351

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the guanine derivative (+/-)-2-amino-1,9-dihydro-9-[(1'alpha,2'beta,3'beta,4'alpha)-(2',3',4'-trihydroxy-l'-cyclopentyl]-6H-purin-6-one (2) is described. This compound is viewed as the carbocyclic ribofuranoside guanine nucleoside analogue lacking the 5'-methylene.

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页码：823 / 825

页数：3

相关论文

共 30 条

[1] AN ENANTIOCONVERGENT ROUTE TO CARBOCYCLIC NUCLEOSIDES (-)-ARISTEROMYCIN AND (-)-NEPLANOCIN A VIA THE ASYMMETRIC DIELS-ALDER REACTION [J].

ARAI, Y ;

HAYASHI, Y ;

YAMAMOTO, M ;

TAKAYEMA, H ;

KOIZUMI, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (12) :3133-3140

[2]

BALZARINI J, 1990, MOL PHARMACOL, V37, P402

[3]

BENNETT LL, 1990, BIOCHEM PHARMACOL, V40, P1515

[4] METABOLISM OF THE CARBOCYCLIC NUCLEOSIDE ANALOG CARBOVIR, AN INHIBITOR OF HUMAN-IMMUNODEFICIENCY-VIRUS, IN HUMAN LYMPHOID-CELLS [J].

BONDOC, LL ;

SHANNON, WM ;

SECRIST, JA ;

VINCE, R ;

FRIDLAND, A .

BIOCHEMISTRY, 1990, 29 (42) :9839-9843

[5] CARBOCYCLIC GLYCINAMIDE RIBONUCLEOTIDE IS A SUBSTRATE FOR GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE [J].

CAPERELLI, CA ;

PRICE, MF .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 264 (01) :340-342

[6] PALLADIUM-ASSISTED ROUTE TO CARBOCYCLIC NUCLEOSIDES - A FORMAL SYNTHESIS OF (+/-)-ARISTEROMYCIN [J].

DEARDORFF, DR ;

SHULMAN, MJ ;

SHEPPECK, JE .

TETRAHEDRON LETTERS, 1989, 30 (48) :6625-6628

[7] ENANTIOSELECTIVE PREPARATION OF FUNCTIONALIZED CYCLOPENTANOIDS VIA A COMMON CHIRAL (PI-ALLYL)PALLADIUM COMPLEX [J].

DEARDORFF, DR ;

LINDE, RG ;

MARTIN, AM ;

SHULMAN, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (11) :2759-2762

[8] MODE OF ACTION OF 9-(4-HYDROXY-3-HYDROXYMETHYLBUT-1-YL)GUANINE (BRL 39123) AGAINST HERPES-SIMPLEX VIRUS IN MRC-5 CELLS [J].

HODGE, RAV ;

PERKINS, RM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (02) :223-229

[9]

JUNG M, 1985, HELV CHIM ACTA, V66, P1915

[10]

KISHI T, 1972, CHEM PHARM BULL, V20, P940