GLC DETERMINATION OF DOXEPIN PLASMA-LEVELS

被引：25

作者：

OBRIEN, JE ^{[1
]}

HINSVARK, ON ^{[1
]}

机构：

[1] PENNWALT CORP, DEPT ANAL CHEM, DIV PHARM, ROCHESTER, NY 14623 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1976年 / 65卷 / 07期

关键词：

D O I：

10.1002/jps.2600650730

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A procedure is described for extracting doxepin, a tricyclic antidepressant, from [human] plasma and subsequently measuring its concentration by GLC. The developed technique permits the resolution and quantitative determination of the cis- and trans-isomers of doxepin as well as its desmethyl metabolite. The method allows precise, reliable measurement of the drug and 1 of its metabolites in concentrations as low as 10 ng/ml of plasma.

引用

页码：1068 / 1069

页数：2