CURATIVE RESECTION OF GASTRIC-CANCER - LIMITATION OF PERITONEAL-LAVAGE CYTOLOGY IN PREDICTING THE OUTCOME

Patients with stage T3NO similar to 2MO gastric carcinoma (n = 108) were studied for relevant prognostic factors. Peritoneal lavage cytology (PLC) was performed in all, In univariate analysis, 5-year survival rates were better with smaller serosal invasion (diameter <3.0 cm vs. greater than or equal to 3.0 cm, 61% vs, 37%, P < 0.05) and fewer metastatic nodes (less than or equal to 5 vs. greater than or equal to 6, 57% vs. 29%, P < 0.05), In multivariate analysis, only these two factors were significant, The predictive value of PLC was not shown in both univariate and multivariate analyses. Peritoneal recurrence occurred in 14 (22%) of 77 patients with negative PLC, and in 3 (18%) of 17 with positive PLC, the difference being not significant. Our results indicate that PLC is insensitive in predicting the development of peritoneal recurrence. Its role in the estimation of survival is limited, as many will die of visceral or locoregional recurrence if not of peritoneal dissemination. (C) 1995 Wiley-Liss, Inc.