SYNTHESIS OF TYROCIDINE-A - USE OF OXIME RESIN FOR PEPTIDE-CHAIN ASSEMBLY AND CYCLIZATION

被引：76

作者：

OSAPAY, G ^{[1
]}

PROFIT, A ^{[1
]}

TAYLOR, JW ^{[1
]}

机构：

[1] ROCKEFELLER UNIV, BIOORGAN CHEM & BIOCHEM LAB, NEW YORK, NY 10021 USA

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)97003-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Application of the Kaiser oxime resin to the synthesis of the thirty-membered ring cyclo-decapeptide Tyrocidine A (TA) is described. Assembly of the linear peptide chain and its subsequent cyclization with concomitant cleavage off the solid support were both achieved in high yield (73.2 % and 55 %). © 1990.

引用

页码：6121 / 6124

页数：4

共 16 条

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