ONE-POT OXAPROPELLANE SKELETON FORMATION BASED ON CONJUGATE ADDITION

被引：6

作者：

FANG, CL ^{[1
]}

SUGANUMA, K ^{[1
]}

SUEMUNE, H ^{[1
]}

SAKAI, K ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 06期

关键词：

D O I：

10.1039/p19910001549

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of five- and/or six-membered-ring ketones 1-5 possessing an omega-halogenoalkyl group and alpha',beta'-unsaturated ester function at the alpha-position with diorganocuprates afforded the oxapropellane compounds 20-24 in a one-pot, three-step procedure via 1,4-addition followed by intramolecular aldol condensation and O-alkylation. Similar reaction of alpha,alpha'-disubstituted cyclopentanone 6 afforded bicyclic products 28 and 29.

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页码：1549 / 1554

页数：6

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