HUMORAL IMMUNITY AGAINST TICK-BORNE ENCEPHALITIS-VIRUS FOLLOWING MANIFEST DISEASE AND ACTIVE IMMUNIZATION

被引：33

作者：

KLOCKMANN, U

BOCK, HL

KWASNY, H

PRAUS, M

CIHLOVA, V

TOMKOVA, E

KRIVANEC, K

机构：

[1] CZECHOSLOVAK ACAD SCI, CS-37005 CESKE BUDEJOVICE, CZECHOSLOVAKIA

[2] DIST HOSP, CS-37005 CESKE BUDEJOVICE, CZECHOSLOVAKIA

来源：

VACCINE | 1991年 / 9卷 / 01期

关键词：

TICK-BORNE ENCEPHALITIS; MANIFEST INFECTION; ELISA; NEUTRALIZATION TITER; HUMORAL IMMUNITY; CEREBROSPINAL-FLUID; ANTIBODIES; EFFICACY; VACCINE;

D O I：

10.1016/0264-410X(91)90315-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humoral immunity against tick-borne encephalitis virus (TBEV) in patients with a well-documented history of naturally acquired tick-borne encephalitis (TBE) was compared with immunity resulting from vaccination in a carefully controlled immunization programme. The vaccination study was performed with a highly purified, inactivated virus particle vaccine and the immune response was followed by tracing the course of IgG antibody formation in an enzyme-linked immunosorbent assay and a neutralization assay. It was shown that this TBE vaccine induced a strong immune response. TBE IgG antibody titres measured after three vaccinations were of the same order of magnitude as those determined in patients recovered from manifest TBE.

引用

页码：42 / 46

页数：5

共 23 条

[1] A NEW VACCINE AGAINST TICK-BORNE ENCEPHALITIS - INITIAL TRIAL IN MAN INCLUDING A DOSE-RESPONSE STUDY [J].