EPSTEIN-BARR-VIRUS TRANSMISSION VIA THE DONOR ORGANS IN SOLID ORGAN-TRANSPLANTATION - POLYMERASE CHAIN-REACTION AND RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS OF IR2, IR3, AND IR4

被引：86

作者：

CEN, H ^{[1
]}

BREINIG, MC ^{[1
]}

ATCHISON, RW ^{[1
]}

HO, M ^{[1
]}

MCKNIGHT, JLC ^{[1
]}

机构：

[1] UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT INFECT DIS & MICROBIOL,PITTSBURGH,PA 15261

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 02期

关键词：

D O I：

10.1128/JVI.65.2.976-980.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two organ transplant recipients who received organs from a common donor and were diagnosed as having an Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder were studied to determine the mode of EBV transmission. The results of restriction fragment length polymorphism, polymerase chain reaction, and minisatellite DNA analyses demonstrate that both patients had a common strain of EBV and that this strain was transmitted from the donor's organs to both recipients. Posttransplant lymphoproliferative disorder resulted from the proliferation of EBV-immortalized B lymphocytes of the recipient, not those of the donor.

引用

页码：976 / 980

页数：5

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