PRESYNAPTIC INHIBITION BY NEUROPEPTIDE-Y OF SLOW INHIBITORY SYNAPTIC TRANSMISSION IN SUBMUCOUS NEURONS OF GUINEA-PIG CECUM

被引：8

作者：

CUNNINGHAM, SMC ^{[1
]}

MIHARA, S ^{[1
]}

LEES, GM ^{[1
]}

机构：

[1] UNIV ABERDEEN MARISCHAL COLL,DEPT BIOMED SCI,ABERDEEN AB9 1AS,SCOTLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1994年 / 79卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1113/expphysiol.1994.sp003760

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The occurrence and disposition of immunoreactivity for neuropeptide Y (NPY) was investigated in the submucosa of guinea-pig caecum. There were few NPY-immunoreactive neurones but intraganglionic varicose fibres were so numerous and strongly immunoreactive that some somata may have been obscured. In each neurone tested, exogenous application of NPY (1-100 nm) depressed the duration and amplitude of the slow inhibitory postsynaptic potential. In contrast, NPY (1-300 nm) had no effects on the resting membrane potential, input resistance and fast and slow excitatory synaptic transmission.

引用

页码：261 / 264

页数：4

共 3 条

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[3] PRESYNAPTIC INHIBITORY EFFECTS OF THE PEPTIDES NPY, PYY AND PP ON NICOTINIC EPSPS IN GUINEA-PIG GASTRIC MYENTERIC NEURONS [J].

SCHEMANN, M ;

TAMURA, K .

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