NEW INSIGHT INTO THE CATALYTIC MECHANISM OF CHORISMATE MUTASES FROM STRUCTURAL STUDIES

被引：110

作者：

LEE, AY

STEWART, JD

CLARDY, J

GANEM, B

机构：

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 04期

关键词：

D O I：

10.1016/1074-5521(95)90269-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chorismate mutase catalyzes the rearrangement of chorismic acid to prephenic acid, which is the first committed step in the biosynthesis of aromatic amino acids. Its catalytic mechanism has been much studied, but is poorly understood. Recent structural information on enzymes from two species, and on an antibody that catalyzes the same reaction, has shed new light on this topic.

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页码：195 / 203

页数：9

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