IN-VITRO STUDIES ON BUCCOADHESIVE TABLET FORMULATIONS OF HYDROCORTISONE HEMISUCCINATE

被引：13

作者：

FABREGAS, JL

GARCIA, N

机构：

[1] Research Center, Laboratorios Almirall, S.A., 08024, Barcelona

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 14期

关键词：

D O I：

10.3109/03639049509069258

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different bioadhesive and matrix-forming polymers were evaluated using ''in-vitro'' tests to identify a potentially convenient ''in-vivo'' formulation for the sustained delivery of hydrocortisone hemisuccinate to the oral cavity. The selected composition allows an erosion-diffusion mechanism coherent with the low hydrosolubility of the drug and with potential advantages for both the patient and the manufacturer.

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页码：1689 / 1696

页数：8

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