EFFECTS OF 1,25-DIHYDROXYCHOLECALCIFEROL ON FRACTURE-HEALING - CALCIUM, PHOSPHATE, AND ZINC IN CALLUS AND SERUM

被引：7

作者：

ANDREEN, O ^{[1
]}

LARSSON, SE ^{[1
]}

机构：

[1] UMEA UNIV, DEPT ORTHOPED SURG, S-90185 UMEA, SWEDEN

来源：

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | 1984年 / 103卷 / 04期

关键词：

D O I：

10.1007/BF00387331

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The incorporation of Ca, phosphate, and Zn into the callus of closed tibial fractures was studied in adult rats fed a standard diet. Low doses (60 ng/kg per day) of 1,25(OH)2D3 5 days a week greatly increased early callus mineralization. This was not related to an increased serum Ca-phosphate M product but rather to a decreased ratio. The incorporation of Zn into callus seemed to be correlated to the mineralization process but not to the 1,25(OH)2D3 administration as such. The question of a direct, indirect, or a complex role of 1,25(OH)2D3 in bone formation and mineralization is discussed.

引用

收藏

页码：257 / 262

页数：6

相关论文

共 37 条

[1] EFFECTS OF PARATHYROIDECTOMY AND VITAMIN-D ON FRACTURE-HEALING - FRACTURE BIOMECHANICS IN RATS AFTER PARATHYROIDECTOMY AND TREATMENT WITH 1,25-DIHYDROXYCHOLECALCIFEROL [J].

ANDREEN, O ;

LARSSON, SE .

ACTA ORTHOPAEDICA SCANDINAVICA, 1983, 54 (06) :805-809

[2] EFFECT OF VITAMIN D ON 65ZN ABSORPTION DISTRIBUTION AND TURNOVER IN RATS [J].

BECKER, WM ;

HOEKSTRA, WG .

JOURNAL OF NUTRITION, 1966, 90 (03) :301-+

[3] TURNOVER OF ZN-65 IN RATS FED A ZINC-DEFICIENT DIET [J].

BERGMAN, B ;

WING, KR .

ACTA PHYSIOLOGICA SCANDINAVICA, 1974, 92 (04) :451-464

[4] BONE-GROWTH IN ORGAN-CULTURE - EFFECTS OF PHOSPHATE AND OTHER NUTRIENTS ON BONE AND CARTILAGE [J].

BINGHAM, PJ ;

RAISZ, LG .

CALCIFIED TISSUE RESEARCH, 1974, 14 (01) :31-48

[5]

BOQUIST L, 1980, UROL RES, V8, P181

[6] EVIDENCE FOR THE PROMOTION OF BONE MINERALIZATION BY 1-ALPHA, 25-DIHYDROXYCHOLECALCIFEROL IN THE RAT UNRELATED TO THE CORRECTION OF DEFICIENCIES IN SERUM-CALCIUM AND PHOSPHORUS [J].

BORIS, A ;

HURLEY, JF ;

TRMAL, T ;

MALLON, JP ;

MATUSZEWSKI, DS .

JOURNAL OF NUTRITION, 1978, 108 (12) :1899-1906

[7] VITAMIN-D AND CARTILAGE .2. BIOLOGICAL-ACTIVITY OF 25-HYDROXYCHOLECALCIFEROL AND 24,25-DIHYDROXYCHOLECALCIFEROLS AND 1,25-DIHYDROXYCHOLECALCIFEROLS ON CULTURED GROWTH PLATE CHONDROCYTES [J].

CORVOL, MT ;

DUMONTIER, MF ;

GARABEDIAN, M ;

RAPPAPORT, R .

ENDOCRINOLOGY, 1978, 102 (04) :1269-1274

[8] LESSON OF THE WEEK - FAILURE TO HEAL VITAMIN-D-DEFICIENCY RICKETS AND SUPPRESS SECONDARY HYPERPARATHYROIDISM WITH CONVENTIONAL DOSES OF 1,25-DIHYDROXY VITAMIN-D3 [J].

CUNDY, T ;

KANIS, JA ;

HEYNEN, G ;

EARNSHAW, M ;

CLEMENS, TL ;

ORIORDAN, JLH ;

MERRETT, AL ;

COMPSTON, JE .

BRITISH MEDICAL JOURNAL, 1982, 284 (6319) :883-885

[9]

DEKEL S, 1979, J BONE JOINT SURG BR, V61, P380

[10] VITAMIN-D - 1973 [J].

DELUCA, HF .

AMERICAN JOURNAL OF MEDICINE, 1974, 57 (01) :1-12

← 1 2 3 4 →