GAMMA-GLUTAMYL-TRANSPEPTIDASE (GGTP) AND NA+K+-ATPASE ACTIVITIES IN DIFFERENT SUBPOPULATIONS OF CLONED CEREBRAL ENDOTHELIAL-CELLS - RESPONSES TO GLIAL STIMULATION

被引：45

作者：

BAUER, HC ^{[1
]}

TONTSCH, U ^{[1
]}

AMBERGER, A ^{[1
]}

BAUER, H ^{[1
]}

机构：

[1] SALZBURG UNIV,INST ZOOL,A-5020 SALZBURG,AUSTRIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91716-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glial stimulation of Na+K+-ATPase and gamma-glutamyl-transpeptidase was taken as parameter for blood brain barrier function in cloned cerebral endothelial cells of different phenotypes. In type I cells ("cobblestone" phenotypus) gamma-glutamyl-transpeptidase activity increased 10-12 fold and Na+K+-ATPase activity was 2-fold increased after glial stimulation. In type II cells ("spindle-form" phenotype) gamma-glutamyl-transpeptidase was only 2-fold increased, whereas Na+K+-ATPase was even depressed. K+-(86Rb) uptake was twice as high in type I cells. These data indicate that type I cells are involved in blood brain barrier function. © 1990.

引用

页码：358 / 363

页数：6

共 23 条

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