PREPARATION, CHARACTERIZATION, AND ANTITUMOR-ACTIVITY OF NEW ETHYLENEDIAMINE PLATINUM(IV) COMPLEXES CONTAINING MIXED CARBOXYLATE LIGANDS

A series of ethylenediamine platinum(IV) complexes of the type Pt(IV)(en)XA2 and Pt(IV)(en)X2'A2, where X = 1,1-cyclobutanedicarboxylato or malonato, X' = chloro, cyclobutanecarboxylato, cyclopentanecarboxylato, or cyclohexanecarboxylato, and A = acetato or trifluoroacetato were synthesized and characterized by elemental analysis, infrared, and NMR (C-13 and Pt-195) spectroscopic techniques. These compounds had good to excellent antitumor activity against murine leukemia L1210 cells. Complexes with axial trifluoroacetate groups were superior to those with acetate ligands. Those possessing both axial trifluoroacetate groups and monodentate bis-carboxylate ligands in the equatorial positions were the most active in the series investigated.