THE CCK-B RECEPTOR ANTAGONIST CI-988 REVERSES TOLERANCE TO MORPHINE IN RATS

被引：47

作者：

HOFFMANN, O

WIESENFELDHALLIN, Z

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT MED LAB SCI & TECHNOL,CLIN NEUROPHYSIOL SECT,S-14186 HUDDINGE,SWEDEN

[2] SABBATSBERGS HOSP,DRUG ABUSE CLIN,STOCKHOLM,SWEDEN

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

PAIN; ANALGESIA; OPIOIDS; CHOLECYSTOKININ;

D O I：

10.1097/00001756-199412000-00040

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE ability of the selective cholecystokinin-B (CCK-B) receptor antagonist CI 988 to reverse tolerance to morphine's antinociceptive effect was investigated with the hot-plate test in Sprague-Dawley rats. Tolerance was induced by subcutaneous (s.c.) injection of 10 mg kg(-11) morphine twice daily for four days. On the fifth day rats were administered CI 988 (10 kg(-1)) or saline plus 5 mg kg(-1) morphine s.c. Significant antinociception was observed in the group that received the CCK-B antagonist plus morphine, whereas the saline plus morphine group exhibited total tolerance. These results suggest that upregulation of the endogenous CCK system during repeated morphine administration may have an important role in the development of opiate tolerance.

引用

页码：2565 / 2568

页数：4

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