THE DEVELOPMENT AND VALIDATION OF AN AGE-STRUCTURED MODEL FOR THE EVALUATION OF DISEASE-CONTROL STRATEGIES FOR INTESTINAL HELMINTHS

被引：53

作者：

CHAN, MS

GUYATT, HL

BUNDY, DAP

MEDLAY, GF

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL, WHO, COLLABORATING CTR EPIDEMIOL INSTESTINAL PARASIT I, LONDON SW7 2BB, ENGLAND

[2] SWISS TROP INST, CH-4002 BASEL, SWITZERLAND

[3] UNIV WARWICK, DEPT BIOL SCI, ECOSYST ANAL & MANAGEMENT GRP, COVENTRY CV4 7AL, W MIDLANDS, ENGLAND

来源：

PARASITOLOGY | 1994年 / 109卷

基金：

英国惠康基金;

关键词：

INTESTINAL NEMATODES; EPIDEMIOLOGIC MODEL; AGE-TARGETED CHEMOTHERAPY; EVALUATION OF CHEMOTHERAPY PROGRAMS; MODEL VERIFICATION;

D O I：

10.1017/S0031182000078422

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Epidemiological modelling can be a useful tool for the evaluation of parasite control strategies. An age-structured epidemiological model of intestinal helminth dynamics is developed. This model includes the explicit representation of changing worm distributions between hosts as a result of treatment, and estimates the morbidity due to heavy infections. The model is used to evaluate the effectiveness of different programmes of age-targeted community chemotherapy in reducing the amount of morbidity due to helminth infection. The magnitude of age-related heterogeneities is found to be very important in determining the results of age-targeted treatment programmes. The model was verified using field data from control programmes for Ascaris lumbricoides and Trichuris is trichiura, and was found to provide accurate predictions of prevalence and mean intensities of infection during and following different control regimes.

引用

页码：389 / 396

页数：8

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