REQUIREMENT FOR TNF-ALPHA AND IL-1-ALPHA IN FETAL THYMOCYTE COMMITMENT AND DIFFERENTIATION

被引：123

作者：

ZUNIGAPFLUCKER, JC ^{[1
]}

JIANG, D ^{[1
]}

LENARDO, MJ ^{[1
]}

机构：

[1] NIAID, IMMUNOL LAB, BETHESDA, MD 20892 USA

来源：

SCIENCE | 1995年 / 268卷 / 5219期

关键词：

D O I：

10.1126/science.7541554

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-alpha or IL-1 alpha was necessary for further thymocyte maturation and CD4(+)CD8(+) differentiation. In irradiated mice reconstituted with CD117(+)CD25(+) thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.

引用

页码：1906 / 1909

页数：4

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