COMPARISON OF THERAPEUTIC EFFICACIES OF TYPE-A AND TYPE-F BOTULINUM TOXINS FOR BLEPHAROSPASM - A DOUBLE-BLIND, CONTROLLED-STUDY

被引:69
作者
MEZAKI, T
KAJI, R
KOHARA, N
FUJII, H
KATAYAMA, M
SHIMIZU, T
KIMURA, J
BRIN, MF
机构
[1] KYOTO UNIV,DEPT NEUROL,KYOTO,JAPAN
[2] CHIBA SERUM INST,CHIBA,JAPAN
[3] COLUMBIA UNIV,COLL PHYS & SURG,DEPT NEUROL,NEW YORK,NY
关键词
D O I
10.1212/WNL.45.3.506
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Type F botulinum toxin can be used for treating patients with dystonia who become refractory to type A toxin injection due to antibody development. We compared the therapeutic efficacy of type F botulinum toxin to that of type A toxin in a self-controlled, double-blind clinical trial. In nine patients with blepharospasm, we injected type A toxin on one side and the same units of type F toxin on the other side. Although the onset of clinical effect, maximal benefit, and adverse reactions were similar between type A and F toxins, the duration of the clinical effect was significantly shorter on the side injected with type F toxin. Although type F toxin proved its promise as an alternative to type A toxin, its usefulness is limited by the shorter duration of action.
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页码:506 / 508
页数:3
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