2 SUCCESSFUL DOUBLE-BLIND TRIALS WITH COENZYME-Q(10) (VITAMIN-Q(10)) ON MUSCULAR-DYSTROPHIES AND NEUROGENIC ATROPHIES

被引:69
作者
FOLKERS, K
SIMONSEN, R
机构
[1] Institute for Biomedical Research, University of Texas at Austin, Austin, TX 78705, and St. David's Medical Plaza
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1995年 / 1271卷 / 01期
关键词
MITOCHONDRION; COENZYME Q(10); MUSCULAR DYSTROPHY; NEUROGENIC ATROPHY;
D O I
10.1016/0925-4439(95)00040-B
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coenzyme Q(10) (vitamin Q(10)) is biosynthesized in the human body and is functional in bioenergetics, anti-oxidation reactions, and in growth control, etc, It is indispensable to health and survival. The first double-blind trial was with twelve patients, ranging from 7-69 years of age, having diseases including the Duchenne, Becker, and the limb-girdle dystrophies, myotonic dystrophy, Charcot-Marie-Tooth disease, and the Welander disease. The control coenzyme Q(10) (CoQ(10)) blood level was low and ranged from 0.5-0.84 mu g/ml. They were treated for three months with 100 mg daily of CoQ(10) and a matching placebo. The second double-blind trial was similar with fifteen patients having the same categories of disease. Since cardiac disease is established to be associated with these muscle diseases, cardiac function was blindly monitored, and not one mistake was made in assigning CoQ(10) and placebo to the patients in both trials. Definitely improved physical performance was recorded. In retrospect, a dosage of 100 mg was too low although effective and safe. Patients suffering from these muscle dystrophies and the like, should be treated with vitamin Q(10) indefinitely.
引用
收藏
页码:281 / 286
页数:6
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