NONIONIC CONTRAST AGENTS PRODUCE THROMBOTIC EFFECT BY INDUCING ADHESION OF LEUKOCYTES ON HUMAN ENDOTHELIUM

被引：14

作者：

ABEYAMA, K

OH, S

KAWANO, K

NAKAJIMA, T

SOEJIMA, Y

NAKANO, K

MARUYAMA, I

机构：

[1] KAGOSHIMA UNIV, FAC MED, DEPT LAB MED, KAGOSHIMA 890, JAPAN

[2] KAGOSHIMA UNIV, FAC MED, DEPT ORAL RADIOL, KAGOSHIMA 890, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of P-selectin was more upregulated following the exposure to nonionic low osmolar contrast agents than to ionic contrast agents. Exposure to nonionic contrast agents led to marked adhesion of leukocytes to endothelial cells. Thrombomodulin activity of endothelial cells was decreased, and plasminogen activator inhibitor-1 (PAI-1) and tumor necrosis factor (TNF) alpha in the supernatant were increased when leukocyte adhesion occurred after exposure to nonionic contrast agents. Results suggest that the adhesion of leukocytes to the endothelium increases procoagulant activity. (C) 1995 Academic Press, Inc.

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页码：776 / 783

页数：8

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