SECRETION OF GAMMA-INTERFERON AT THE CELLULAR-LEVEL - INDUCTION BY EPSTEIN-BARR VIRUS

被引：25

作者：

ANDERSSON, U

MARTINEZMAZA, O

ANDERSSON, J

BRITTON, S

GADLER, H

DELEY, M

MODROW, S

机构：

[1] KAROLINSKA INST, DEPT IMMUNOBIOL, WALLENBERG LAB, S-10405 STOCKHOLM, SWEDEN

[2] NATL BACTERIOL LAB, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN

[3] CATHOLIC UNIV LEUVEN, REGA INST MED RES, DEPT HUMAN BIOL, DIV MICROBIOL, B-3000 LOUVAIN, BELGIUM

[4] MAX VON PETTENKOFER INST, MUNICH, FED REP GER

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1984年 / 20卷 / 05期

关键词：

D O I：

10.1111/j.1365-3083.1984.tb01021.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a hemolytic plaque assay for .gamma.-interferon (IFN-.gamma.) secretion it was found that in vitro Epstein-Barr virus (EBV) exposure of peripheral blood mononuclear cells from EBV immune individuals led to IFN-.gamma. secretion, which was apparent within 6 h after virus contact and peaked 12-24 h after induction. Live, UV-light-irradiated and heat-inactivated virions all caused IFN-.gamma. secretion. Blood mononuclear cells from EBV non-immune adults or neonates could not be activated to IFN-.gamma. production by EBV.

引用

页码：425 / 432

页数：8

共 33 条

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